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In July 2015, Eileen is informed by Gail that her good friend Deirdre has died. She and Liz recollect their fond memories of Deirdre, before attending her funeral. Eileen’s history includes numerous failed romances. Her first known screen partner was Dennis Stringer (Charles Dale), who left her in 2001 following an affair with her best friend at the time, Janice Battersby. Next, Eileen fell for Ed Jackson (Chris Walker) in 2006, before discovering he had served time in prison for killing Emily Bishop’s husband Ernest in a storyline that screened in 1978. Commenting on Eileen’s relationship with Ed, Sue Cleaver has said, “She’d have loved it to work with Ed but she knew it wouldn’t while he was on a mission to absolve himself of his sins. It would be great if Chris came back. I loved working with him, and he really would like to come back.” Eileen first appears on 3 May 2000. Vikram Desai (Chris Bisson) gives Eileen a ride in his cab and, impressed by her local knowledge, ends up employing her to operate the radio at his taxi firm, StreetCars, which he runs with Steve McDonald (Simon Gregson). She demands £5.50 an hour.On Christmas Day 2006, Eileen is surprised when a young woman drops a baby off, claiming that Jason is the father. Eileen takes responsibility for the little girl, whom they call Holly because she arrives during the Christmas period. Jason does not want her and tells Eileen that she is not his, but Eileen refuses to believe him, so Jason ends up calling Children’s Services in desperation. He admits that he called them, but he is fond of baby Holly. However, Eileen is shocked on 9 April 2007 when Holly’s mother returns as she has realised that Charlie Stubbs (Bill Ward) is Holly’s real father, after seeing his picture in the paper during Tracy Barlow’s (Kate Ford) trial. She tells Eileen that he introduced himself as Jason Grimshaw and asks Eileen to give Holly back but Eileen refuses and throws her out, threatening to call the police. Knowing that Eileen has no legal claim to the woman’s daughter, she calls Children’s Services and they tell Eileen that they will be coming to collect Holly so Eileen decides to run away with her. Eileen’s nemesis, Gail Platt, finds out and persuades her to return Holly to her mother. A tearful Eileen returns Holly on 25 April 2007.
Eileen has had many relationships since the character’s introduction. Her relationship with biker Dennis Stringer (Charles Dale) ends when he admits he is love with Janice Battersby (Vicky Entwistle), resulting in Eileen punching Janice. Following Jason and Candice Stowe (Nikki Sanderson) placing an ad for her in a lonely hearts column in a newspaper, she dates cleaner Harry Flagg (Iain Rogerson) but they decide to remain friends. She dates Ernest Bishop’s killer, Ed Jackson (Chris Walker), despite disapproval from most of the Street. It is during this relationship with Ed, a born-again Christian, that Eileen comes to the conclusion that she is agnostic. In 2007, she meets Pat Stanaway (Sean Hughes), who she assumes is married and has an “affair”. Pat is not married as he does not like serious relationships as he was dating six other women at the time. She dates kebab shop owner Jerry Morton (Michael Starke), but dumps him in 2008 after he begins taking more of an interest in his children rather than her.
Eileen is thrilled when her son Todd returns, although it becomes clear he has changed while he has been in London. She is forced to give him £500 so that he can pay back the people he has scammed money off. Eileen then learns that Todd cheated on his former boyfriend Jools Creme (Ben Allen) as he had an affair with a man named Alex. She is later shaken when Jason’s estranged father Tony Stewart (Terence Maynard) returns to the street in 2014, and is not very pleased when Liz begins flirting with him. She is later unhappy when she discovers that Todd has had sex with Marcus Dent (Charlie Condou), who is in a serious relationship with Maria Connor (Samia Ghadie). She later begins a feud with Liz when she learns that she has entered a relationship with Tony and is later ashamed of Todd when his affair with Marcus is revealed. She has several arguments with Liz over Tony, and Liz later thinks that Eileen is jealous. As the feud progresses, Liz and Eileen eventually forgive one another. Eileen is later concerned when her friend Lloyd suffers a heart attack during Hayley Cropper’s (Julie Hesmondhalgh) charity fun run.Eileen Grimshaw (also Phelan) is a fictional character from the British ITV soap opera Coronation Street. Portrayed by Sue Cleaver, the character first appeared on-screen during the episode airing on 3 May 2000. Her storylines have often included her relationships with Dennis Stringer (Charles Dale), Ed Jackson (Chris Walker), Pat Stanaway (Sean Hughes), Jerry Morton (Michael Starke), Jesse Chadwick (John Thomson), Paul Kershaw (Tony Hirst), Adrian Mortimer (Mark Moraghan) and Michael Rodwell (Les Dennis), as well as her marriage to serial criminal mastermind Pat Phelan (Connor McIntyre).
The character has been involved in various feuds since her introduction in 2000. Eileen’s most prominent and long-running feud has been with Gail Platt, played by Helen Worth. The characters have a long history of catfights and insults between them, animosity that stems from the acrimonious break-up of Eileen’s son, Todd and Gail’s daughter, Sarah. In one famous scene, Gail flings herself at Eileen after being soundly slapped and told to “Go home, Gail!” Despite this, various things, including the 2010 tram crash, have caused them to put aside their differences. In 2015, Eileen knew Gail past and discover that it her feud with her was like her former mother-in-law Ivy Tilsley. Cleaver has commented, “Eileen’s relationship with Gail is horrendous […] I love all the scraps in the street with Gail. Helen Worth (who plays Gail) and I love doing all that – we have such a laugh with the abusive comments we make for each other. The constant battle is fun. It’s a love-hate relationship.” Worth has suggested that Gail probably thinks she is “a little better than Eileen” Jenny Platt, who played Violet Wilson between 2004 and 2008 has noted that “Gail’s found her nemesis in Eileen, but it’s so stupid because actually they are so similar. They are both single mums looking out for their kids.”
Media critic Grace Dent has summarised the dislike that exists between the characters in a review in The Guardian in 2006: “Like most fine inter-family feuds, no one knows the true beginning, but it’s safe to say that Coronation Street’s Eileen Grimshaw and Gail Platt have hated each other for ages. Eileen sees Gail’s daughter Sarah Lou as a giant, repugnant, mascara-clad Venus flytrap, suckering in baby-daddies for her illegitimate brat Bethany. Gail Platt thinks Eileen’s kids Todd and Jason are scummy, duplicitous, gutter-dwellers and their mother a snivelling apologist for their catalogue of spite. When Eileen’s son, Todd, dated Sarah-Lou, he passed up the chance to s
tudy at Oxford University […] When eventually Eileen stopped fantasising about trapping Sarah-Lou’s head in Fred Elliott’s bacon slicer, Sarah-Lou had set her eye on Todd’s half-brother Jason. Both Gail and Eileen took this news with deep umbrage. Eileen knew Jason could do much better than this drippy, yo-yo-knickered little strumpet. Meanwhile, Gail knew Sarah-Lou was worth more than that slack-jawed, apostolic follower of Charlie Stubbs.”It has been noted that Eileen has “not had much luck in love”, although Cleaver maintains that viewers should not feel sorry for her character, adding that Eileen is “very happy” and “together”. She adds, “People forget that she’s had proposals of marriage and turned them down.”
It was announced in 2007 that comedian Sean Hughes would be joining Coronation Street as Pat, a love interest for Eileen. A source told Daily Mirror, “They meet in the [Rovers Return] and get on like a house on fire. It’s not very long before they are enjoying steamy sessions. It’s a great coup to have Sean play the role. It’s a mixture of serious and comical. He and Sue have a good chemistry to make the story work really well”. However, the relationship soured when Eileen discovered he was a serial womanizer. A romance with Jerry Morton fizzled out on-screen in 2008, when Eileen dumped him. Actor Michael Starke, who was axed from his role as Jerry Morton in 2008, has been critical about the way Eileen and Jerry’s romance “died such an early death”. In an interview, he commented, “There was even talk of babies! But it fizzled out – it went absolutely nowhere. It was never explained to me”.A feisty single mum, Eileen comes from a family of eight. She rents Steve’s house and moves in with her teenage sons, Jason (Ryan Thomas) and Todd (Bruno Langley). In the early days, she does not approve of Jason’s aspirations to be an athlete. A couple of years later, Todd comes out as gay.
Cleaver has stated that there are similarities between her own personality and Eileen’s: “On a soap, you can’t come in and create a character that’s very far removed from yourself, because it’s such a lot of work, so of course there are elements to Eileen that I’ve brought in. But I think we’re very different. She’s more generous than I am quite frankly!” She has added, “I think Eileen is happy. She’s a very together person […] She’s got a very realistic view […] I think there are a lot of women who would aspire to be like her, how she holds everything together and juggles her job, the kids and everyone else’s problems.”
On 12 December 2008, Eileen’s father Colin (Edward DeSouza) arrives. He meets Peter Barlow (Chris Gascoyne) in the bookies and as he places a bet, Eileen phones him wanting to know where he is and he lies, claiming to be on the bus to Weatherfield. He was known for his betting and drinking and this causes a row when they meet.In February 2009, Eileen is stunned to discover that an old school friend of hers, Paula Carp (Sharon Duce), left school early after falling pregnant at fourteen years old. When she learns that Street resident, Julie Carp (Katy Cavanagh), is Paula’s daughter. When Paula finds out that Julie and Eileen live on the same street, she begins acting strangely and is hostile to Colin when she sees him. On 27 April 2009, during Colin’s seventieth birthday party in The Rovers, Eileen is horrified to learn that Colin is Julie’s father after a drunken Paula reveals the truth, making Julie and Eileen half-sisters. Struggling with this bombshell, Eileen blames Paula for wrecking her parents’ marriage as Eileen had blamed her mother but realises that Paula was a victim of abuse and makes amends with her a few days later. When Colin visits, trying to explain his actions, Eileen is disgusted. During the visit, Colin suffers a stroke, but Eileen refuses to take him to hospital. He is released from hospital and Jason and Julie convince Eileen to let him stay with her until they can find him somewhere to live but he dies of a heart attack.
The character also appeared in the mini-episode crossover between Coronation Street and rival soap EastEnders entitled East Street screened on 19 November 2010 in aid of children’s charity Children In Need. In 2011, it was revealed that she and half-sister Julie Carp (Katy Cavanagh) were related to Coronation Street icon, Elsie Tanner (Pat Phoenix), as Elsie’s first cousin, Arnley Grimshaw, was their paternal grandfather. In 2018, Cleaver took a temporary break from the show.Eileen meets Paul Kershaw (Tony Hirst), a fireman, when her head is caught in the railings on her birthday on Underworld’s roof. They start dating, but Marcus sees Paul with another woman in Freshco’s, making Eileen angry so she visits Paul to demand answers and Paul’s wife, Lesley (Judy Holt), answers the door. Eileen shouts at Lesley but she is confused. Paul comes to the door and tells Lesley to go inside, explaining to Eileen that Lesley has Alzheimer’s disease, which explained why she didn’t understand Eileen’s question. Eileen and Paul stay friends and Paul helps Eileen when Eileen told Sunita that she would get somebody for the local school’s safety day. Eileen invites Paul and Lesley to her house for Christmas dinner but they pull out after Lesley has a fall. Eileen goes on a speed dating night at Nick Tilsley’s (Ben Price) Bistro and meets a man called Hank. They soon argue which ends up in Eileen pushing Hank into the fire alarm. Paul comes to the scene expecting a fire but Eileen asks him for a drink. One day, Paul asks Eileen if she would take care of Lesley while he is at work. Eileen does so, but she later regrets it when Lesley beats her up and physically throws her out of her own home. Jason takes Eileen to the café to calm down, but while she is at the café, Lesley dies after being electrocuted by the toaster. After Lesley’s funeral, Paul and Eileen become a proper couple. Eileen becomes suspicious that Paul is having an affair with his colleague Toni, but he is actually planning a romantic proposal. Paul walks out and goes to The Rovers soon followed by Eileen who asks for forgiveness. Paul gets down on one knee and asks her to marry him.In July 2010, builder Owen Armstrong (Ian Puleston-Davies) catches Eileen’s eye and she is delighted when they date a few times and does some admin work at the builder’s yard. However, Owen is more interested in Eileen’s friend, Liz McDonald (Beverley Callard) and he starts dating her behind Eileen’s back. Eileen is disgusted when she discovers that Owen and Liz are an item and plots revenge on Owen for the way he used her. In January 2011, Eileen discovers that her roof has been damaged after the tram crash and asks Owen to have a look. He tells her that the tiles are damaged and there is water damage in the interior walls, costing about £3,000 to fix. Eileen gets an insurance inspector to have a look but Jason thinks he is spying on his girlfriend, Rosie Webster (Helen Flanagan), and punches him so the inspector refuses to help Eileen; who steals a cheque for £10,000 that Carla Connor (Alison King) has left for Owen and cashes it. Owen finds out and offers to have a look at the house and tells Eileen that he knows she has taken his money and she will pay for it. Upset, she tells Julie what has happened and they devise a plan to break into the builder’s yard to get documents that prove that Owen has been committing tax evasion for years. The sisters successfully blackmail Owen with this so he agrees to fix the roof. Several weeks later, Owen gets revenge for Eileen’s blackmail by letting himself into her house and retrieving the paperwork Eileen stole after she tells Sunita Alahan about his dodgy business practices. He destroys the evidence and calls the police, reporting Eileen for the cheque she stole and she is arrested for fraud. Eileen admits her guilt and, as it is her first offence and she returned the money, she is released with a caution.
Eileen eventually comes to terms with Paul working at the fire station. Whilst playing darts at the Rovers with Jason and Steve, an oblivious Paul makes a racist comment just as Lloyd Mullaney (Craig Charles) and his daughter Jenna Kamara (Krissi Bohn) enter the pub, which angers them both as they are black. Paul is infuriated when Lloyd casts him a racist, and the pair nearly come to blows in The Rovers. Soon, the whole Street assume that Paul is racist, which makes Eileen feel ashamed. Paul will not apologise to Lloyd as he fears he will actually be considered a racist if he does. Eileen and Lloyd’s partner Mandy Kamara (Pamela Nomvete) both agree that the pair should put it behind them, which it appears to be, before Jenna’s girlfriend Sophie Webster (Brooke Vincent) calls Paul’s work and reports him for racism. Paul’s boss pays him a visit at Eileen’s house, suspending him from work until further investigation. Paul sees red and punches Lloyd in the street, as many locals watch in horror. Before the pair descend into fighting, two policemen arrive and split them up. Paul is arrested and questioned, but the whole event leads to further strain on his and Eileen’s relationship. Eileen later watches as Paul shouts at Sophie in the street, which leads to Eileen and Sophie’s mother Sally Webster (Sally Dynevor) sharing a scrap in The Rovers. The feud puts pressure on Lloyd and Mandy’s relationship too, which results in Mandy leaving Weatherfield. Paul invites Lloyd, Steve and Brian to a few drinks in town, but is furious when his mates from the fire station do not attend. He says it is because they think he is a racist, and he shouts at Lloyd when a group of men approach them. Later, as Lloyd is leaving the pub, the group of men attack him, pinning him up the wall and it transpires that they are a gang of racists. Paul arrives and saves Lloyd, which puts the arguing behind them. They arrive back in Weatherfield to reveal the good news to Eileen, but she is not impressed as Paul did not do anything about it sooner. They discuss how supportive she was when Lesley was alive, and how Paul would have left Eileen if Lesley did not have Alzheimer’s disease. She then runs upstairs in anger. There is further upset for Eileen when Paul leaves Weatherfield for good.
Sue Cleaver has revealed that she received letters of complaint from viewers when Eileen was shown to have a one-night stand with a boilerman: “I had so many letters of complaint about the one night stand she had with the boiler man. People said she wouldn’t do that. She bloody well would! She’s got two kids, she’s been around the block a bit.” In 2009, Digital Spy editor Kris Green praised Sue Cleaver’s part in the Julie/ Paula/ Colin reveal when he stated; ‘The outstanding performances from Katy Cavanagh (Julie) and Sharon Duce (Paula) mixed with Street legend Barbara Knox (Rita) and the still criminally underused Sue Cleaver (Eileen) make for compelling viewing’ Sarah Ellis of Inside Soap opined that “poor” Eileen should join a convent because all of her romances end badly.
One of Eileen’s most enduring on-screen relationships has been her friendship with her boss Steve McDonald (Simon Gregson). Cleaver has said that she enjoys Eileen’s “constant bickering with Steve”. She has revealed that she and Gregson play jokes with the bookings diary on Eileen’s desk during filming of the cab office, where both characters work: “We write comments about each other in it. When you see me scribbling in the book, think of the rudest things possible and they’re in there”. In 2007, both characters were featured in a special week of off-set episodes, filmed on location in Malta. The friends decide to take a trip together amid Steve’s relationship problems with Michelle Connor. A Coronation Street spokesperson said: “We’re excited about going out to film this storyline in Malta. Both Steve and Eileen’s love lives are looking pretty bleak, so they decide to escape to the sunshine. It’ll be great fun.” Press rumo
urs began to circulate about a possible romantic pairing between the characters; however, this proved to be a red herring, Eileen spends the night in bed with a drunken Steve to avoid sleeping in discomfort on the floor. During the episodes, some of Malta’s historic streets and churches, landscapes and Gozo’s red sand beach Ramla Bay were featured. It was predicted in the media that British tourism trade to Malta would significantly increase due to the screening of the episodes. When discussions about filming on the island began, UK-based site YourMalta.com commented, “it could be a major boost […] A half hour episode on Malta will reach more people over a longer period of time than a tourist authority could hope to with a series of twenty or thirty second advertisements, it would be worth millions in equivalent advertising.” Property website easier.com stated that “viewers have been captivated by the sun-soaked honey-coloured buildings, the charming historic streets and churches and beautiful landscapes not to mention the glorious red sand beach of Ramla Bay. It was hard not to be envious as Eileen and Steve sipped cocktails next to the pool in the gleaming sunshine and this lifestyle was all the more alluring when the camera’s panned back to the dreary streets of Weatherfield.”
Eileen finds it difficult to get to sleep at night, worrying about Paul and whether he has died in a fire while at work. She decides to take some sleeping pills, but ends up falling asleep at work. When she wakes up, she is rude to Gary Windass (Mikey North) and is confronted by her colleagues, Steve and Lloyd Mullaney (Craig Charles). Eileen hears from her lodger Sean and son Jason that there has been a large house fire in Weatherfield and asks Paul whether he had been called to it when he returns. He tells Eileen he had been on a hoax call, but then reveals to Sean and Jason that he had been saving people from the house fire. The next day, a young boy named Paddy Kinsey (Sonny Cusworth), his mother Megan (Louise Atkins) and news reporter Will Reade (Dominic Doughty) arrive at Eileen and Paul’s house and Eileen discovers that Paul was in fact at the house fire and not at a hoax call. Paddy, Megan and Will reveal how serious the fire was, which stuns Eileen, Jason and Sean. This infuriates Eileen, as Paul decided to lie to her instead of telling her the truth.
What is the biggest lion hybrid?
The liger The liger is a hybrid offspring of a male lion (Panthera leo) and a tigress, or female tiger (Panthera tigris). The liger has parents in the same genus but of different species. The liger is distinct from the similar hybrid called the tigon, and is the largest of all known extant felines.
After an argument with Todd, Eileen orders him to leave the family home, and while he is walking the streets in town, Todd is violently mugged and beaten up by a gang of thugs. He is rushed to hospital, and is told that he may have permanent scarring on his face. He blames Eileen and Jason for the attack, however keeps this to himself. In 2015, Eileen begins internet dating and meets a man named Adrian Mortimer (Mark Moraghan). She goes out with Adrian on numerous occasions, but Todd – attempting to exact revenge on his mother and brother for his attack – sets up a fake account on the same website and pretends to be a man named Jeff who lives in Dubai. Eileen soon decides that she prefers Jeff to Adrian, much to Todd’s delight. Todd also makes Jason believe that his girlfriend Eva Price (Catherine Tyldesley) is having an affair with Tony, leading to Eva moving to New York to live with her mother as she believes Jason does not trust her. After Eileen reveals to Adrian that things are not working out, Todd arrives and reveals to a heartbroken Adrian that Eileen has met somebody else and reveals that he is Jeff. He also reveals that he broke Jason and Eva up, leading to Jason punching Todd in the face. Todd then leaves Weatherfield after the heated argument, and Eileen is distraught at how evil Todd has become. Eileen allows Michael Rodwell (Les Dennis) to move in with her after he discovers that his wife, Gail, lied to her about his son, Gavin (Mark Holgate), and discovering that Andy Carver (Oliver Farnworth) has been pretending to be his son. After a public argument with Gail, Michael gets drunk with Eileen, leading to them kissing. As they begin to have sex, Michael collapses and suffers a heart attack, leaving Eileen heavily humiliated. Michael admits the kiss with Gail out of guilt, but she storms over to the salon and starts throwing hair conditioner bottles at Eileen. The fight spills into the street, with Gail throwing her shoe at Eileen and Eileen pushing Gail to the ground.In 2009, Eileen starts dating children’s entertainer, Jesse Chadwick (John Thomson). He moves into Eileen’s house, along with his parrot named John. In 2010, cracks begin appearing in the relationship after Eileen suspects that he is attracted to Julie and he takes his parents on holiday instead of her, following a bet that he wins. Eileen throws him out but he returns, attempting to reconcile with her but Eileen insists that he leave after she discovers that he made a pass at Julie.Eileen Grimshaw has been described as “a firm favourite with fans”. Actress Sue Cleaver has commented on her character’s popularity to the Belfast Telegraph in 2007: “Everyone seems to love Eileen. I’ve never had anybody come up and say they don’t like her, so I suppose that’s a good thing. She’s an accessible character and I think everybody knows an Eileen. There’s an Eileen in every street.” Low Culture columnist Ruth Deller has included the character as one of the best soap creations during the 2000s. She stated, “Eileen arrived as the decade was just beginning and she’s kept us entertained throughout. Sue Cleaver is great and so is the character. A classic soap matriarch she has the potential to be one of the most enduring and popular characters the Street has ever seen.” In 2007, actress Sue Cleaver was recognised for her role as Eileen with a TV Now award for ‘Favourite Female Soap Star’.
Eileen has been described as “a down-to-earth, pragmatic type of character”. Sue Cleaver has expressed how much she likes the variation in Eileen’s development, with storylines ranging from “comic capers” to “serious”: “I lurch between the light-hearted and serious. There’s been lots of heavy drama stuff with [Eileen’s sons] Todd and Jason. So it’s really nice to have the relief of the scenes in the taxi office, [Eileen’s workplace], where it’s more upbeat. I get to play the whole spectrum, which is fun […] As an actor, you do not often get an opportunity to keep building on your character and finding new aspects to them. If you’re doing a film or TV series, it’s over in three months, whereas in something long-running, I can really understand my character and know them inside out like another human being. The challenge is to delve a little bit deeper into Eileen’s psyche, which I really enjoy doing.”
Eileen’s arch enemy is Gail Rodwell (Helen Worth) and they have had several fights in the street. The pair constantly spar whenever they cross paths. The feud begins when her son, Todd, moves in with Gail’s daughter, Sarah (Tina O’Brien) as Eileen feels that Sarah, a single mother, is holding Todd back from achieving in life. This seems to be proved when Sarah falls pregnant, but the baby, a boy named Billy, died shortly after being born prematurely following a placental abruption. Todd’s announcement that he is gay and having an affair with Karl Foster causes a catfight in the street. The two women are at loggerheads again when they are attracted to reflexologist Phil Nail (Clive Russell); Gail eventually wins his affections. This rivalry results in Eileen being the prime suspect when Gail is stalked by someone claiming to be her late husband, Richard Hillman (Brian Capron), in 2006. Eileen is cleared when David Platt (Jack P. Shepherd) is revealed as the true culprit. Eileen’s son Jason married Gail’s daughter Sarah in October 2007, and divorced in 2010.As Paul, Jason and other men from Weatherfield take part in The Full Monty evening at the Bistro for charity, The Rovers is set on fire by Karl Munro, as part of an elaborate plan he has devised to win back ex-fiancée Stella. Norris Cole (Malcolm Hebden) alerts the Bistro, and Eileen is horrified when she witnesses Paul risk his life to save Stella Price (Michelle Collins) and Karl Munro (John Michie) from the burning building. Luckily, Paul manages to save himself, Stella and Karl from the flames, but Paul’s friend Toni Griffiths (Tara Moran) perishes as the roof collapses on her. The next day, Paul grieves for Toni, and Eileen is petrified of Paul returning to work in case he dies like Toni did. After numerous arguments and several weeks off work, Paul finally returns to work at the fire station, worrying Eileen. Convinced Paul is not ready to return to work after Toni’s death, Eileen visits Paul’s boss and asks if he can have more time off. Unfortunately for Eileen, Paul walks in on her and his boss discussing this. The pair return home where they have an explosive argument and Paul decides to move in with Julie and her partner Brian Packham (Peter Gunn). This infuriates Eileen, leading to her rowing with Julie in the café. Eileen discovers the tickets for her and Paul’s holiday to Egypt come through the door, and decides to take Julie on the holiday instead. She later regrets this when Julie says she wants to have an adventure with Eileen, whereas Eileen just wants to relax and forget all her troubles on the holiday. Paul reveals he is leaving the Street to work in North Yorkshire, upsetting Eileen. Her friend Deirdre Barlow (Anne Kirkbride) convinces her to go and find Paul and tell him not to leave her. She does so, and Paul and Eileen reunite as a couple, much to Deirdre and Julie’s pleasure.
Is chimera good or bad?
Role-playing. In the roleplaying game Dungeons & Dragons, the chimera is an evil-aligned creature which looks like a lion with leathery wings on its back. To either side of its lion’s head is the head of a goat and the head of a dragon.
In the Iron Age the griffin was again prominent in both Asia and Greece. Greek metalworkers evolved a handsome stylized rendering, the beak open to show a curling tongue and the head provided with horses’ ears and a large knob on top. Apparently the griffin was in some sense sacred, appearing frequently in sanctuary and tomb furnishings. Its precise nature or its place in cult and legend remains unknown.griffin, also spelled griffon or gryphon, composite mythological creature with a lion’s body (winged or wingless) and a bird’s head, usually that of an eagle. The griffin was a favourite decorative motif in the ancient Middle Eastern and Mediterranean lands. Probably originating in the Levant in the 2nd millennium bce, the griffin had spread throughout western Asia and into Greece by the 14th century bce. The Asiatic griffin had a crested head, whereas the Minoan and Greek griffin usually had a mane of spiral curls. It was shown either recumbent or seated on its haunches, often paired with the sphinx; its function may have been protective.
Does chimera exist today?
Cases of human chimeras have been documented. This condition is either innate or it is synthetic, acquired for example through the infusion of allogeneic blood cells during transplantation or transfusion. In nonidentical twins, innate chimerism occurs by means of blood-vessel anastomoses.
To enhance your search results and narrow down your query, you can refine them by specifying the number of letters in the desired word. Additionally, if you already know certain letters within the word, you can provide them in the form of a pattern using the symbol “?” to represent unknown letters. Let’s take an example pattern: “d?f???ul?”.
Upon examining the given clues, we have managed to identify a total of 1 possible solutions for the crossword clue „Creature which is part lion and part eagle“. In an effort to arrive at the correct answer, we have thoroughly scrutinized each option and taken into account all relevant information that could provide us with a clue as to which solution is the most accurate.
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Chimera, originally found in Greek mythology, is a monstrous fire-breathing creature composed of the parts of multiple animals. The term, and often the general concept, has since been adopted by various works of popular culture, and chimeras of differing description can be found in contemporary works of fantasy and science fiction. Sean began visiting Dylan and Violet in London. On one visit on Easter Sunday in 2011, Sean was surprised to find Marcus at Violet and Jamie’s residence. As Marcus and Violet were both going through relationship troubles, the two men took Dylan out for the day, but upon returning saw Jamie departing in a cab, seemingly ending their relationship. A sympathetic Sean offered to look after Dylan for a while but Violet accused him of trying to steal her son, and told him that the Violet he once knew was now gone. Sean retaliated by accusing Violet of being homophobic and not wanting to pollute Dylan with his mannerisms. He subsequently left and returned home. In 2006, Sean reunited with his ‘father’ Brian Tully, who had left his mother for another woman when Sean was ten years old. On Father’s Day 2006, Brian revealed that he was not Sean’s biological father, and that Sean’s mother had in fact been having an affair with another man – a plumber called Paul Jones, who did not know that Sean existed.
Kelly once tried to seduce Sean even though she knew he was gay. When he defended himself against her physical advances, he ended up giving her a bruise. Kelly was angry at him and cost him his job by claiming the bruise was from some kind of assault. Sean later got his job back and forgave Kelly. Despite these events, Kelly and Sean remained friends.
In July 2009 Sean fell for a gay man named Leon whilst attending Weatherfield Health & Fitness with Jason. Trying to impress Leon, Sean claimed that Jason was his boyfriend, and during a later session at the gym, feigned being upset claiming that Jason had “dumped” him in order to invoke sympathy. This backfired however, when Leon stated he wasn’t interested in camp men, and later admitted to Sean that he was in love with Jason. Sean tried to tell Leon that Jason wasn’t gay, but he refused to believe him. After Jason won Mr Gay Weatherfield while drunk, the pair were forced to admit to Leon that Jason was straight. A shocked Leon then reported Jason and had him disqualified from the competition.
Sean decided to track down Dylan in 2010, but worried that Violet would turn him away, sent a friend request on Facescene posing as Liz McDonald, although initially angry, Liz became sympathetic as Sean only wanted to find his son, so she contacted Violet who then sent Sean a request on his own account as well as photographs of a two-year old Dylan.
In 2007, Sean impregnated his friend Violet Wilson in order to give her a baby, with the understanding that he would play no part in the child’s upbringing, however when Dylan was born, Sean reneged on the deal causing Violet to flee Weatherfield with Jamie Baldwin. Though he eventually traced his son to London in 2011, Sean’s role in Dylan’s life was limited to the occasional visit until 2022, when Dylan persuaded him and Violet to let him have an extended stay in Weatherfield.On 29th February, Jamie, Violet and Dylan left the Street but Violet’s sister, Lauren, told Sean that they were leaving. Sean refused to believe that they were leaving forever and later blamed himself. Eventually he had to admit they had gone for good. When Sean was jealous of Marcus staying with an ex in London, it became clear that it was time to move on. On 3rd September 2008, at a party at Liam’s, Sean fell for Tom Kerrigan. Sean asked Tom if he minded if he kissed him, Tom declined and Sean stormed off. Nevertheless, Sean and Marcus split a couple of days later.
After weeks living rough, Sean’s predicament was discovered by Billy, who then offered him to move in with him at 19a Rosamund Street, which Sean reluctantly accepted after he was forced to finally ask for help. Sean managed to get his old jobs back at Underworld and the Rovers Return respectively, and was back on the rebound.
The character of Sean Tully was introduced for a one-off basis in July 2003. Ten months later, he appeared for a further two episodes in April 2004, before returning as a regular character four months later from August onwards.Sean wears his heart on his sleeve and often struggles to maintain serious relationships. The two main loves of his life, sonographer Marcus Dent and vicar Billy Mayhew, left him for Maria Connor and Todd Grimshaw respectively, with the latter causing him to be kicked out of No.11 after twelve years. In February 2007, Michelle Connor introduced Sean to her new boyfriend, Sonny Dhillon. Sean recognised Sonny as a former boyfriend. Sean confronted Sonny about their past relationship. Later, they rekindled their affair, but were soon discovered by both Jamie Baldwin and Steve McDonald. Michelle’s brothers, Liam and Paul, questioned Sean about Steve’s claims and later forced him to admit the truth to Michelle, devastingly ending her betrothal to Sonny. He had a very brief relationship with veterinarian Tim White. Sean gained employment at Underworld, where he made friends with Fiz Brown and Kelly Crabtree. His former boss Danny Baldwin’s nickname for him was “Mincemeat”. He also got a second job in the Rovers Return as a barman.The transitory nature of Sean’s life has meant that he often lives on the breadline. A notable low point came in 2018 when, after losing both of his jobs and home, he had to beg on the streets. He was rescued by Billy, who let him move into 19a Rosamund Street until he got back on his feet. He is now back at No.11 with Eileen, Dylan, and Todd.
Sean and Billy split up in 2016. In August, Sean demanded Eileen to pick between him and Todd after he found Todd and Billy all over each other. Pat Phelan manipulated Eileen into picking Todd so Sean left and moved into 3 Coronation Street.
In April 2004, he was seen again when Karl Foster and Todd Grimshaw had a night out on Manchester’s Canal Street. In August of that year, he turned up in Coronation Street, looking for somewhere to live. Todd’s mother, Eileen Grimshaw, took a shine to him and invited him to be her lodger, much to the chagrin of her other son, Jason Grimshaw. When Eileen and Jason fell out over Todd moving away, Eileen asked Sean to move out for a while so she could mend her relationship with Jason. Sean later moved back in.Following Tyrone and Fiz’s split after it was discovered that Tyrone had slept with Gemma Winter during a rift with Fiz, Sean continued staying at No. 9 with Fiz, and Tyrone moved in with business partner Kevin Webster. Sean was concerned when Fiz hoped for reconciliation with Tyrone, and wanted him to find a place of his own. Although Fiz’s hopes at getting back with Tyrone was temporarily on hold, she wished to have her own independence with the girls and felt she was relying too much on Sean to do the housework. Sean was very concerned as he had barely any money to his name to find a new place, but chose not to tell Fiz about his problems and began desperately searching for local jobs as well as contacting old acquaintances for lodgings. In July 2018, Liz offered Sean a place to stay, however, she changed her mind after he got her old job behind the bar at the Rovers following her sacking, and thinking that Sean deliberately betrayed her; she told him that he could forget about moving in. Sean attempted at one last ditch effort to find lodgings, but it proved unsuccessful. After his shift, he found an old tent in the bin and set it up in the park where he secretly began living in after moving out of Fiz’s. Sean was involved in a plot with Violet Wilson and Jamie Baldwin, when Violet became convinced that Jamie was in love with Sean, only to find that Jamie was actually in love with his stepmum, Frankie Baldwin. Sean also appeared in East Street, a crossover sketch made for the BBC’s Children in Need in 2010, which featured characters from the BBC’s soap EastEnders visiting Coronation Street while other Corrie residents visited Albert Square.In June 2007, Sean decided to be a sperm donor to Violet. After visiting the hospital with Violet for her twelve-week scan, Sean got the number of the sonographer, Marcus Dent, and started a romance with him. They went through a rough patch when Sean tricked his boyfriend into revealing the sex of the baby, totally disrespecting Violet as she didn’t want to know whilst Sean did. It was revealed that Violet was expecting a boy. Sean and Violet fell out due to the fact that Sean wanted to be the baby’s father but Violet saw him as the sperm donor as they had originally agreed. Sean looked into legal advice about the situation but it was too expensive. He and Violet finally called a truce and Sean lent Violet and Jamie the money for a flat together. Unfortunately Violet and Jamie found Sean’s attention suffocating and agreed to move down to London together for a fresh start as a family. However, Violet went into labour at the Rovers Return on 22nd February, whilst Jamie was moving their things down to London, so Sean had to stay for the birth of his son. When he was born, Sean shouted out that he was the first person his son had seen. He was then seen bonding with his son whilst Violet was in hospital, upsetting Jamie who planned to be his father.
In 2017, Sean took a job at Rosamund Street Medical Centre where he was sacked after only a few months for breaking patient confidentiality. At the start of 2018, Sean had more trouble when he accidentally deleted photos of baby George Appleton on a computer so was kicked out of No.3 by Angie Appleton. Sean then moved in with close friends Fiz and Tyrone Dobbs at 9 Coronation Street. Sean took control of the family, as Fiz was away, and undertook numerous household chores, including washing, cooking and cleaning; as well as taking care of Ruby Dobbs and Hope Stape. When Tyrone and Sean went out for a meal together as a pretend couple in order to get a free dinner, they were mistaken for actually being a couple and a photograph of the pair kissing spread around the street.
Sean arrived in Coronation Street in 2004 in his search for lodgings. There he found a home at No.11 and, following his sacking from a cosmetics firm, became Underworld’s first male machinist. Sean quickly became a surrogate son to his landlady Eileen Grimshaw, but he would forever play second fiddle to her sons Todd and Jason. As well as the factory, Sean has been a barman at
the Rovers Return since 2005 and took over the catering upon Betty Williams’s death in 2012, being entrusted with her famous hotpot recipe at the same time.Marcus later returned to Weatherfield and Sean reconciled their relationship. Over the summer they took care of Dylan after Violet ended up in hospital. In late-2012, the relationship ended after Marcus discovered he had feelings for Maria Connor and got together with her, which left Sean single once again.
Chimera, in Greek mythology, a fire-breathing female monster resembling a lion in the forepart, a goat in the middle, and a dragon behind. She devastated Caria and Lycia until she was slain by Bellerophon. In art the Chimera is usually represented as a lion with a goat’s head in the middle of its back and with a tail that ends in a snake’s head. This matches the description found in Hesiod’s Theogony (7th century bc). The word is now used generally to denote a fantastic idea or figment of the imagination.
The first known primate chimeras are the rhesus monkey twins, Roku and Hex, each having six genomes. They were created by mixing cells from totipotent four-cell morulas; although the cells never fused, they worked together to form organs. It was discovered that one of these primates, Roku, was a sexual chimera; as four percent of Roku’s blood cells contained two x chromosomes.A major milestone in chimera experimentation occurred in 1984 when a chimeric sheep–goat was produced by combining embryos from a goat and a sheep, and survived to adulthood.
All plastid gene- and some nuclear gene-differential chimeras affect the color of the plasmids within the leaves, and these are grouped together as chlorophyll chimeras, or preferably as variegated leaf chimeras. For most variegation, the mutation involved is the loss of the chloroplasts in the mutated tissue, so that part of the plant tissue has no green pigment and no photosynthetic ability. This mutated tissue is unable to survive on its own, but it is kept alive by its partnership with normal photosynthetic tissue. Sometimes chimeras are also found with layers differing in respect of both their nuclear and their plastid genes.In nonidentical twins, innate chimerism occurs by means of blood-vessel anastomoses. The likelihood of offspring being a chimera is increased if it is created via in vitro fertilisation. Chimeras can often breed, but the fertility and type of offspring depends on which cell line gave rise to the ovaries or testes; varying degrees of intersex differences may result if one set of cells is genetically female and another genetically male.
Chimeric mice are important animals in biological research, as they allow for the investigation of a variety of biological questions in an animal that has two distinct genetic pools within it. These include insights into problems such as the tissue specific requirements of a gene, cell lineage, and cell potential.These chimeras arise by spontaneous or induced mutation of a nuclear gene to a dominant or recessive allele. As a rule, one character is affected at a time in the leaf, flower, fruit, or other parts.
Tetragametic chimerism is a form of congenital chimerism. This condition occurs through the fertilization of two separate ova by two sperm, followed by aggregation of the two at the blastocyst or zygote stages. This results in the development of an organism with intermingled cell lines. Put another way, the chimera is formed from the merging of two nonidentical twins (a similar merging presumably occurs with identical twins, but as their genotypes are not significantly distinct, the resulting individual would not be considered a chimera). As such, they can be male, female, or have mixed intersex characteristics.
Untransformed cells should be easy to detect and remove to avoid chimeras. This is because it is important to maintain the stable ability of the transgenic plants across different generations. Reporter genes such as GUS and Green Fluorescent Protein (GFP) are utilized in combination with plant selective markers (herbicide, antibody etc.) However, GUS expression depends on the plant development stage and GFP may be influenced by the green tissue autofluorescence. Quantitative PCR could be an alternative method for chimera detection.
A genetic chimerism or chimera (/kaɪˈmɪərə, kə-/ ky-MEER-ə, kə-) is a single organism composed of cells with more than one distinct genotype. In animals and human chimeras, this means an individual derived from two or more zygotes, which can include possessing blood cells of different blood types, subtle variations in form (phenotype) and, if the zygotes were of differing sexes, then even the possession of both female and male sex organs. Animal chimeras are produced by the merger of two (or more) embryos. In plant chimeras, however, the distinct types of tissue may originate from the same zygote, and the difference is often due to mutation during ordinary cell division. Normally, genetic chimerism is not visible on casual inspection; however, it has been detected in the course of proving parentage. In contrast, an individual where each cell contains genetic material from two organisms of different breeds, varieties, species or genera is called a hybrid.
Chimerism has been found in some species of marine sponges. Four distinct genotypes have been found in a single individual, and there is potential for even greater genetic heterogeneity. Each genotype functions independently in terms of reproduction, but the different intra-organism genotypes behave as a single large individual in terms of ecological responses like growth.(4) The observable characteristic of transgenic cells may be a transient expression of the marker gene. Or it may due to the presence of agrobacterium cells.
The US and Western Europe have strict codes of ethics and regulations in place that expressly forbid certain subsets of experimentation using human cells, though there is a vast difference in the regulatory framework. Through the creation of human chimeras comes the question: where does society now draw the line of humanity? This question poses serious legal and moral issues, along with creating controversy. Chimpanzees, for example, are not offered any legal standing, and are put down if they pose a threat to humans. If a chimpanzee is genetically altered to be more similar to a human, it may blur the ethical line between animal and human. Legal debate would be the next step in the process to determine whether certain chimeras should be granted legal rights. Along with issues regarding the rights of chimeras, individuals have expressed concern about whether or not creating human chimeras diminishes the “dignity” of being human.
While German dermatologist Alfred Blaschko described Blaschko’s lines in 1901, the genetic science took until the 1930s to approach a vocabulary for the phenomenon. The term genetic chimera has been used at least since the 1944 article of Belgovskii.In contrast, a human where each cell contains genetic material from two organisms of different breeds, varieties, species or genera is called a human–animal hybrid.
What happened to Eileen and Dennis?
Eileen has had many relationships since the character’s introduction. Her relationship with biker Dennis Stringer (Charles Dale) ends when he admits he is love with Janice Battersby (Vicky Entwistle), resulting in Eileen punching Janice.
It has been shown that yellow crazy ants are obligate chimeras, the first known such case. In this species the queens have arisen from fertilized eggs with a genotype of RR (Reproductive x Reproductive), the sterile female workers show a RW arrangement (Reproductive x Worker), and the males instead of being haploid as is usually the case for ants also display a RW genotype, but for them the egg R and the sperm W do not fuse so they develop as a chimera with some cells carrying an R and others carrying a W genome.
What is the hybrid of lion and eagle?
The griffin The griffin, griffon, or gryphon (Ancient Greek: γρύψ, gryps; Classical Latin: grȳps or grȳpus; Late and Medieval Latin: gryphes, grypho etc.; Old French: griffon) is a legendary creature with the body, tail, and back legs of a lion; the head and wings of an eagle; and sometimes an eagle’s talons as its front feet.
Most chimeras will go through life without realizing they are chimeras. The difference in phenotypes may be subtle (e.g., having a hitchhiker’s thumb and a straight thumb, eyes of slightly different colors, differential hair growth on opposite sides of the body, etc.) or completely undetectable. Chimeras may also show, under a certain spectrum of UV light, distinctive marks on the back resembling that of arrow points pointing downwards from the shoulders down to the lower back; this is one expression of pigment unevenness called Blaschko’s lines.
On January 22, 2019 the National Society of Genetic Counselors released an article — Chimerism Explained: How One Person Can Unknowingly Have Two Sets of DNA, where they state “Tetragametic Chimerism, where a twin pregnancy evolves into one child, is currently believed to be one of the rarer forms. However, we know that 20 to 30% of singleton pregnancies were originally a twin or a multiple pregnancy. Due to this statistic, it is quite possible that tetragametic chimerism is more common than current data implies”.
In artificial chimerism, an individual has one cell lineage that was inherited genetically at the time of the formation of the human embryo and the other that was introduced through a procedure, including organ transplantation or blood transfusion. Specific types of transplants that could induce this condition include bone marrow transplants and organ transplants, as the recipient’s body essentially works to permanently incorporate the new blood stem cells into it.These are produced by grafting genetically different parents, different cultivars or different species (which may belong to different genera). The tissues may be partially fused together following grafting to form a single growing organism that preserves both types of tissue in a single shoot. Just as the constituent species are likely to differ in a wide range of features, so the behavior of their periclinal chimeras is like to be highly variable. The first such known chimera was probably the Bizzaria, which is a fusion of the Florentine citron and the sour orange. Well-known examples of a graft-chimera are Laburnocytisus ‘Adamii’, caused by a fusion of a Laburnum and a broom, and “Family” trees, where multiple varieties of apple or pear are grafted onto the same tree. Many fruit trees are cultivated by grafting the body of a sapling onto a rootstock.
Who is the machinist friend of Eileen in Corrie?
Sean Tully is a machinist at Underworld and long-time lodger of Eileen Grimshaw. Sean arrived in Coronation Street in 2004 in his search for lodgings.
As the organism develops, it can come to possess organs that have different sets of chromosomes. For example, the chimera may have a liver composed of cells with one set of chromosomes and have a kidney composed of cells with a second set of chromosomes. This has occurred in humans, and at one time was thought to be extremely rare although more recent evidence suggests that this is not the case.In August 2003, researchers at the Shanghai Second Medical University in China reported that they had successfully fused human skin cells and rabbit ova to create the first human chimeric embryos. The embryos were allowed to develop for several days in a laboratory setting, and then destroyed to harvest the resulting stem cells. In 2007, scientists at the University of Nevada School of Medicine created a sheep whose blood contained 15% human cells and 85% sheep cells.
What creature is part lion and part eagle?
The Griffin is a mythical creature known as a half-eagle, half-lion in various cultures. In legends and folklore, the beast guards the gold of the kings, as well as other priceless possessions.
Chimerism occurs naturally in adult Ceratioid anglerfish and is in fact a natural and essential part of their life cycle. Once the male achieves adulthood, it begins its search for a female. Using strong olfactory (or smell) receptors, the male searches until it locates a female anglerfish. The male, less than an inch in length, bites into her skin and releases an enzyme that digests the skin of both his mouth and her body, fusing the pair down to the blood-vessel level. While this attachment has become necessary for the male’s survival, it will eventually consume him, as both anglerfish fuse into a single hermaphroditic individual. Sometimes in this process, more than one male will attach to a single female as a symbiote. In this case, they will all be consumed into the body of the larger female angler. Once fused to a female, the males will reach sexual maturity, developing large testicles as their other organs atrophy. This process allows for sperm to be in constant supply when the female produces an egg, so that the chimeric fish is able to have a greater number of offspring. This is particularly true for the marmoset. Recent research shows most marmosets are chimeras, sharing DNA with their fraternal twins. 95% of marmoset fraternal twins trade blood through chorionic fusions, making them hematopoietic chimeras. In 2012, the first example of a naturally-occurring RNA-DNA hybrid virus was unexpectedly discovered during a metagenomic study of the acidic extreme environment of Boiling Springs Lake that is in Lassen Volcanic National Park, California. The virus was named BSL-RDHV (Boiling Spring Lake RNA DNA Hybrid Virus). Its genome is related to a DNA circovirus, which usually infect birds and pigs, and a RNA tombusvirus, which infect plants. The study surprised scientists, because DNA and RNA viruses vary and the way the chimera came together was not understood.
These chimeras arise by spontaneous or induced mutation of a plastid gene, followed by the sorting-out of two kinds of plastid during vegetative growth. Alternatively, after selfing or nucleic acid thermodynamics, plastids may sort-out from a mixed egg or mixed zygote respectively. This type of chimera is recognized at the time of origin by the sorting-out pattern in the leaves. After sorting-out is complete, periclinal chimeras are distinguished from similar looking nuclear gene-differential chimeras by their non-mendelian inheritance. The majority of variegated-leaf chimeras are of this kind.
Another case was that of Karen Keegan, who was also suspected (initially) of not being her children’s biological mother, after DNA tests on her adult sons for a kidney transplant she needed, seemed to show she was not their mother.Some level of chimerism occurs naturally in the wild in many animal species, however in some cases may be a required (obligate) part of their life cycle.
An animal chimera is a single organism that is composed of two or more different populations of genetically distinct cells that originated from different zygotes involved in sexual reproduction. If the different cells have emerged from the same zygote, the organism is called a mosaic. Innate chimeras are formed from at least four parent cells (two fertilised eggs or early embryos fused together). Each population of cells keeps its own character and the resulting organism is a mixture of tissues. Cases of human chimeras have been documented. It is possible to dissect the embryo at other stages so as to accordingly give rise to one lineage of cells from an embryo selectively and not the other. For example, subsets of blastomeres can be used to give rise to chimera with specified cell lineage from one embryo. The Inner Cell Mass of a diploid blastocyst, for example, can be used to make a chimera with another blastocyst of eight-cell diploid embryo; the cells taken from the inner cell mass will give rise to the primitive endoderm and to the epiblast in the chimera mouse. From this knowledge, ES cell contributions to chimeras have been developed. ES cells can be used in combination with eight-cell-and two-cell-stage embryos to make chimeras and exclusively give rise to the embryo proper. Embryos that are to be used in chimeras can be further genetically altered in order to specifically contribute to only one part of chimera. An example is the chimera built off of ES cells and tetraploid embryos, which are artificially made by electrofusion of two two-cell diploid embryos. The tetraploid embryo will exclusively give rise to the trophectoderm and primitive endoderm in the chimera. Another way that chimerism can occur in animals is by organ transplantation, giving one individual tissues that developed from a different genome. For example, transplantation of bone marrow often determines the recipient’s ensuing blood type.A major mechanism of human chimerism is mosaicism, wherein there is a mutation of the genetic material in a cell, giving rise to a subset of cells that are different from the rest. Another mechanism is the fusion of more than one fertilized zygote in the early stages of prenatal development. Microchimerism is the presence of a small number of cells that are genetically distinct from those of the host individual. Most people are born with a few cells genetically identical to their mothers’ and the proportion of these cells goes down in healthy individuals as they get older. People who retain higher numbers of cells genetically identical to their mother’s have been observed to have higher rates of some autoimmune diseases, presumably because the immune system is responsible for destroying these cells and a common immune defect prevents it from doing so and also causes autoimmune problems. The higher rates of autoimmune diseases due to the presence of maternally-derived cells is why in a 2010 study of a 40-year-old man with scleroderma-like disease (an autoimmune rheumatic disease), the female cells detected in his blood stream via FISH (fluorescence in situ hybridization) were thought to be maternally-derived. However, his form of microchimerism was found to be due to a vanished twin, and it is unknown whether microchimerism from a vanished twin might predispose individuals to autoimmune diseases as well. Mothers often also have a few cells genetically identical to those of their children, and some people also have some cells genetically identical to those of their siblings (maternal siblings only, since these cells are passed to them because their mother retained them). The tetragametic state has important implications for organ or stem cell transplantation. Chimeras typically have immunologic tolerance to both cell lines. There are a variety of combinations that can give rise to a successful chimera mouse and – according to the goal of the experiment – an appropriate cell and embryo combination can be picked; they are generally but not limited to diploid embryo and ES cells, diploid embryo and diploid embryo, ES cell and tetraploid embryo, diploid embryo and tetraploid embryo, ES cells and ES cells. The combination of embryonic stem cell and diploid embryo is a common technique used for the making of chimeric mice, since gene targeting can be done in the embryonic stem cell. These kinds of chimeras can be made through either aggregation of stem cells and the diploid embryo or injection of the stem cells into the diploid embryo. If embryonic stem cells are to be used for gene targeting to make a chimera, the following procedure is common: a construct for homologous recombination for the gene targeted will be introduced into cultured mouse embryonic stem cells from the donor mouse, by way of electroporation; cells positive for the recombination event will have antibiotic resistance, provided by the insertion cassette used in the gene targeting; and be able to be positively selected for. ES cells with the correct targeted gene are then injected into a diploid host mouse blastocyst. Then, these injected blastocysts are implanted into a pseudo pregnant female surrogate mouse, which will bring the embryos to term and give birth to a mouse whose germline is derived from the donor mouse’s ES cells. This same procedure can be achieved through aggregation of ES cells and diploid embryos, diploid embryos are cultured in aggregation plates in wells where single embryos can fit, to these wells ES cells are added the aggregates are cultured until a single embryo is formed and has progressed to the blastocyst stage, and can then be transferred to the surrogate mouse. Germline chimerism occurs when the germ cells (for example, sperm and egg cells) of an organism are not genetically identical to its own. It has been recently discovered that marmosets can carry the reproductive cells of their (fraternal) twin siblings due to placental fusion during development. (Marmosets almost always give birth to fraternal twins.) To research the developmental biology of the bird embryo, researchers produced artificial quail-chick chimeras in 1987. By utilizing transplantation and ablation in the chick embryo stage, the neural tube and the neural crest cells of the chick were ablated, and replaced with the same parts from a quail. Once hatched, the quail feathers were visibly apparent around the wing area, whereas the rest of the chick’s body was made of its own chicken cells. The ability to make mouse chimeras comes from an understanding of early mouse development. Between the stages of fertilization of the egg and the implantation of a blastocyst into the uterus, different parts of the mouse embryo retain the ability to give rise to a variety of cell lineages. Once the embryo has reached the blastocyst stage, it is composed of several parts, mainly the trophectoderm, the inner cell mass, and the primitive endoderm. Each of these parts of the blastocyst gives rise to different parts of the embryo; the inner cell mass gives rise to the embryo proper, while the trophectoderm and primitive endoderm give rise to extra embryonic structures that support growth of the embryo. Two- to eight-cell-stage embryos are competent for making chimeras, since at these stages of development, the cells in the embryos are not yet committed to give rise to any particular cell lineage, and could give rise to the inner cell mass or the trophectoderm. In the case where two diploid eight-cell-stage embryos are used to make a chimera, chimerism can be later found in the epiblast, primitive endoderm, and trophectoderm of the mouse blastocyst.
The general methods for creating chimeric mice can be summarized either by injection or aggregation of embryonic cells from different origins. The first chimeric mouse was made by Bea
trice Mintz in the 1960s through the aggregation of eight-cell-stage embryos. Injection on the other hand was pioneered by Richard Gardner and Ralph Brinster who injected cells into blastocysts to create chimeric mice with germ lines fully derived from injected embryonic stem cells (ES cells). Chimeras can be derived from mouse embryos that have not yet implanted in the uterus as well as from implanted embryos. ES cells from the inner cell mass of an implanted blastocyst can contribute to all cell lineages of a mouse including the germ line. ES cells are a useful tool in chimeras because genes can be mutated in them through the use of homologous recombination, thus allowing gene targeting. Since this discovery occurred in 1988, ES cells have become a key tool in the generation of specific chimeric mice.
These are chimeras in which the layers differ in their chromosome constitution. Occasionally, chimeras arise from loss or gain of individual chromosomes or chromosome fragments owing to misdivision. More commonly cytochimeras have simple multiple of the normal chromosome complement in the changed layer. There are various effects on cell size and growth characteristics.This condition is either innate or it is synthetic, acquired for example through the infusion of allogeneic blood cells during transplantation or transfusion.
What has happened to Eileen in Coronation Street?
Eileen was written out of the show temporarily, after being invited to Thailand by her son Jason. In new scenes set to air next week, Eileen returns home from her trip abroad, where she’s welcomed by Todd, Sean and Mary.
Though ligers typically have a life expectancy of between 13 and 18 years, they are occasionally known to live into their 20s. A ligress named Shasta was born at the Hogle Zoo in Salt Lake City on 14 May 1948 and died in 1972 at age 24. Nook, a liger at a facility in Wisconsin, died in 2007, at 21 years old. Hobbs, a male liger at the Sierra Safari Zoo in Reno, Nevada, lived to almost 15 years of age before succumbing to liver failure, and weighed 450 kg (992 lb).It is sometimes wrongly believed that ligers continue to grow throughout their lives because of hormonal issues. It may be that they simply grow far more during their growing years and take longer to reach their full adult size. Further growth in shoulder height and body length is not seen in ligers over six years old, as in both lions and tigers. Male ligers also have the same levels of testosterone on average as an adult male lion, yet are azoospermic in accordance with Haldane’s rule. In addition, female ligers may also attain great size, weighing approximately 320 kg (705 lb) and reaching 3.05 m (10 ft) long on average, and are often fertile. In contrast, pumapards (hybrids between pumas and leopards) tend to exhibit dwarfism.
Although ligers are more commonly found than tigons today, in At Home in the Zoo (1961), Gerald Iles wrote “For the record I must say that I have never seen a liger, a hybrid obtained by crossing a lion with a tigress. They seem to be even rarer than tigons.” Two liger cubs born in 1837 were exhibited to King William IV and to his successor Queen Victoria. On 14 December 1900 and on 31 May 1901, Carl Hagenbeck wrote to zoologist James Cossar Ewart with details and photographs of ligers born at the Hagenbeck’s Tierpark in Hamburg in 1897. As with the tigon, the liger exists only in captivity. Historically, the Asiatic lion and the Bengal tiger co-occurred in some Asian countries, and there are legends of male lions mating with tigresses in the wilderness, or of ligers existing there. The two species’ ranges are known to overlap in India’s Gir National Park, though no ligers were known to live there until the modern era. The range of the Caspian tiger has overlapped with that of the lion in places such as northern Iran and eastern Anatolia.
The United States holds the greatest population of around 30 ligers. China holds about 20 ligers. There are a few countries worldwide that hold a few, but probably fewer than 100 exist worldwide.
The liger is a hybrid offspring of a male lion (Panthera leo) and a tigress, or female tiger (Panthera tigris). The liger has parents in the same genus but of different species. The liger is distinct from the similar hybrid called the tigon, and is the largest of all known extant felines. They enjoy swimming, which is a characteristic of tigers, and are very sociable like lions. Notably, ligers typically grow larger than either parent species, unlike tigons.
What is the eagle lion mix called?
griffin, also spelled griffon or gryphon, composite mythological creature with a lion’s body (winged or wingless) and a bird’s head, usually that of an eagle.
Panthera hybrids tend to experience a higher rate of injury and neurological disorder than non-hybrids. Though not universal, ligers and tigons may develop health issues. Organ failure issues have been reported in ligers, in addition to neurological deficits, sterility, cancer, and arthritis.
Hercules, the largest non-obese liger, is recognised by the Guinness Book of World Records as the largest living cat on Earth, weighing 418.2 kg (922 lb). Hercules was featured on the Today Show, Good Morning America, Anderson Cooper 360, Inside Edition, and in a Maxim article in 2005, when he was only three years old and already weighed 408.25 kg (900 lb).The fertility of hybrid big cat females is well documented across a number of different hybrids. This is in accordance with Haldane’s rule: in hybrids of animals whose sex is determined by sex chromosomes, if one of the two sexes is absent, rare or sterile, it will be the heterogametic sex. Male ligers are consequently sterile, while female ligers are not.
In 1935, four ligers from two litters were reared in the Zoological Gardens of Bloemfontein, South Africa. Three of them, a male and two females, were still living in 1953. The male weighed 340 kg (750 lb) and stood a foot and a half (45 cm) taller than a full grown male lion at the shoulder.
It has remained for one of the most enterprising collectors and naturalists of our time, Mr. Carl Hagenbeck, not only to breed but to bring successfully to a healthy maturity, specimens of this rare alliance between those two great and formidable Felidae, the lion and tiger. The illustrations will indicate sufficiently how fortunate Mr. Hagenbeck has been in his efforts to produce these hybrids. The oldest and biggest of the animals shown is a hybrid born on the 11th May 1897. This fine beast, now more than five years old, equals and even excels in his proportions a well-grown lion, measuring as he does from nose tip to tail 10 ft 2 inches in length, and standing only three inches less than 4 ft at the shoulder. A good big lion will weigh about 400 lb […] the hybrid in question, weighing as it does no less than 467 lb, is certainly the superior of the most well-grown lions, whether wild-bred or born in a menagerie. This animal shows faint striping and mottling, and, in its characteristics, exhibits strong traces of both its parents. It has a somewhat lion-like head, and the tail is more like that of a lion than of a tiger. On the other hand, it has no trace of mane. It is a huge and very powerful beast.The breeding of ligers and other Panthera hybrids has come under fire from animal rights activists and organisations, who argue that the health problems experienced by these animals makes their creation immoral. Despite these assertions of immorality, some unlicensed zoos still breed ligers for profit. The liger is often believed to be the largest cat in the world. Males reach a total length of 3 to 3.6 m (9.8 to 11.8 ft), which means that they rival even large male lions and tigers in length. Imprinted genes may be a factor contributing to the large size of ligers. These are genes that may or may not be expressed on the parent they are inherited from, and that occasionally play a role in issues of hybrid growth. For example, in some dog breed crosses, genes that are expressed only when maternally-inherited cause the young to grow larger than is typical for either parent breed. This growth is not seen in the paternal breeds, as such genes are normally “counteracted” by genes inherited from the female of the appropriate breed. The liger has a faint tiger-like striped pattern upon a lionesque tawny background. In addition, it may inherit rosettes from the lion parent (lion cubs are rosetted and some adults retain faint markings). These markings may be black, dark brown or sandy. The background color may be correspondingly tawny, sandy or golden. In common with tigers, as an example of countershading, the underparts are pale. The specific pattern and color depend upon which subspecies the parents were and how the genes interact in the offspring. In 1825, G. B. Whittaker made an engraving of liger cubs born in 1824. The parents and their three liger offspring are also depicted with their trainer in a 19th-century painting in the naïve style. The history of lion-tiger hybrids dates to at least the early 19th century in India. In 1798, Étienne Geoffroy Saint-Hilaire (1772–1844) made a colour plate of the offspring of a lion and a tiger. The name “liger”, a portmanteau of lion and tiger, was coined by the 1930s. “Ligress” is used to refer to a female liger, on the model of “tigress”.
White tigers have been crossed with lions to produce “white” (actually pale golden) ligers. In theory, white tigers could be crossed with white lions to produce white, very pale or even stripeless ligers. There are no black ligers. Very few melanistic tigers have ever been recorded, most being due to excessive markings (pseudo-melanism or abundism) rather than true melanism; no reports of black lions have ever been substantiated. As blue or Maltese tigers probably no longer exist, gray or blue ligers are exceedingly improbable. It is not impossible for a liger to be white, but it is very rare. The first known white ligers were born in December 2013 at Myrtle Beach Safari in Myrtle Beach, South Carolina to a white male lion and a white female tiger.
Other big cat hybrids can reach similar sizes; the litigon, a rare hybrid of a male lion and a female tigon, is roughly the same size as the liger, with a male named Cubanacan (at the Alipore Zoo in India) reaching 363 kg (800 lb). The extreme rarity of these second-generation hybrids may make it difficult to ascertain whether they are larger or smaller, on average, than the liger.Ligers and tigons were long thought to be totally sterile. However, in 1943, a fifteen-year-old hybrid between a lion and an island tiger was successfully mated with a lion at the Munich Hellabrunn Zoo. The female cub, though of delicate health, was raised to adulthood.In September 2012, the Russian Novosibirsk Zoo announced the birth of a “liliger”, the offspring of a liger mother and a lion father. The cub was named Kiara.
Is Chimera a lion?
In art the Chimera is usually represented as a lion with a goat’s head in the middle of its back and with a tail that ends in a snake’s head. This matches the description found in Hesiod’s Theogony (7th century bc). The word is now used generally to denote a fantastic idea or figment of the imagination.
Three gryphons form the crest of Trinity College, Oxford (founded 1555), originating from the family crest of founder Sir Thomas Pope. The college’s debating society is known as the Gryphon, and the notes of its master emeritus show it to be one of the oldest debating institutions in the country, significantly older than the more famous Oxford Union Society. Griffins are also mascots for VU University Amsterdam, Reed College, Sarah Lawrence College, the University of Guelph, and Canisius College.In Dante Alighieri’s Divine Comedy, after Dante and Virgil’s journey through Hell and Purgatory has concluded, Dante meets a chariot dragged by a griffin in Earthly Paradise. Immediately afterwards, Dante is reunited with Beatrice. Dante and Beatrice then start their journey through Paradise.
In the sitcom The Big Bang Theory, Dr. Sheldon Cooper mentions that he attempted to create a griffon but could not obtain the “necessary eagle eggs and lion semen.”
Because the lion was traditionally considered the king of the beasts, and the eagle the king of the birds, by the Middle Ages, the griffin was thought to be an especially powerful and majestic creature. Since classical antiquity, griffins were known for guarding treasures and priceless possessions.
The griffin is the symbol of the Philadelphia Museum of Art; bronze castings of them perch on each corner of the museum’s roof, protecting its collection.The opinicus or epimacus is another heraldic variety of griffin, which is depicted with all four legs being those of a lion. Occasionally, its tail may be that of a camel or its wings may be absent. The opinicus is rarely used in heraldry, but appears in the arms of the Worshipful Company of Barbers. It is sometimes wingless.
An archaic griffin design, created by artist Thomas Fanourakis [el] (1915–1993), was adopted as the official symbol of the city of Heraklion on 22 March 1961 (cf. figure right).
A number of medieval griffin’s claws existed, sometimes purported to be very large. St. Cuthbert is said to have obtained claw and egg: two claws and two eggs were registered in the 1383 inventory of the saint’s shrine, but the two-feet claws that still remain on display have been identified as Alpine ibex horns.